Prevalence of plasmid-mediated quinolone resistance pdf

Only a few previous studies examined the prevalence of quinoloneresistance in the kingdom of saudi arabia ksa and showed it is increasing. The prevalence of plasmidmediated quinolone resistance genes in escherichia coli isolated from hospital wastewater sources in tehran, iran. Prevalence and characterization of plasmidmediated quinolone resistance genes among escherichia coli strains isolated from different water sources in alborz province, iran. In the present study, we investigated the prevalence of plasmidmediated quinolone resistance determinants among a collection of extendedspectrum. Detection of chromosomal and plasmidmediated quinolone. Plasmidmediated quinolone resistance was thus rare in the sample examined.

Infection and drug resistance the prevalence of plasmid mediated quinolone resistance and esblproduction in enterobacteriaceae isolated from urinary tract infections mohammad reza sadeghi 0 mohammad hossein soroush barhaghi 1 hossein samadi kafil 1 3 fatemeh yeganeh 1 mahin ahangar oskouee 1 reza ghotaslou 1 2 0 azad university of macu, macu, iran 1 microbiology department, school of. Ibcr and qepa genes was evaluated in a collection of 281. We studied 1,058 isolates that had been consecutively collected in 66 hospitals of the whonetargentina resistance surveillance network. Pdf the prevalence of plasmidmediated quinolone resistance. Prevalence of plasmidmediated quinolone resistance determinants over a 9year period. High prevalence of the plasmidmediated quinolone resistance.

High prevalence of plasmidmediated quinolone resistance. Boukadida laboratory of microbiology immunology ur12sp34, chu farhat hached teaching hospital, sousse, tunisia corresponding author abstract. Full text investigation of six plasmidmediated quinolone resistance. Pdf prevalence of plasmidmediated quinolone resistance in. Sixteen percent of those isolates carried qnr genes encoding the qnrb1, qnrb2, qnra6 or qnrs1. Plasmidmediated quinolone resistance among nontyphi. The prevalence of plasmid mediated quinolone resistance and esblproduction in enterobacteriaceae isolated from urinary tract infections robab azargun,1,2 mohammad reza sadeghi,3 mohammad hossein soroush barhaghi,2 hossein samadi kafil,2,4 fatemeh yeganeh,2 mahin ahangar oskouee,2 reza ghotaslou1,2 1infectious and tropical diseases research center, tabriz university of medical sciences, tabriz. Ibcrpositive isolate were detected, representing 0. Data concerning the prevalence of these determinants in upec in our hospital are quite limited. To evaluate the temporal change in the prevalence of pmqr genes over a decade in a tertiary hospital in the republic of korea, we selected every fifth isolate of escherichia coli and klebsiella pneumoniae and every third isolate of enterobacter cloacae. Prevalence of plasmidmediated quinolone resistance genes in. Prevalence and genetic analysis of plasmidmediated quinolone resistance determinants qnra and qnrs in enterobacteriaceae isolates from a french university hospital. Ibcr, and qepa in a total of 185 nonduplicate salmonella spp.

Prevalence of plasmidmediated quinolone resistance in multidrug. Prevalence of plasmidmediated quinolone resistance genes among extendedspectrum lactamaseproducing klebsiella pneumoniae human isolates in iran ehsanehshams, 1 farzanehfiroozeh, 1 rezvanmoniri, 1 andmohammadzibaei 2 department of microbiology and immunology, school of medicine, kashan university of medical sciences, p. Prevalence of plasmidmediated quinolone resistance in norwegian and swedish clinical isolates of escherchia coli and klebsiella spp. By using pcr, a high prevalence of the plasmid mediated quinolone resistance determinant qnra was detected 15 of 47 32% ciprofloxacin and cefotaximeresistant enterobacteriaceae isolated from bacteraemic patients at the rluh. This study was conducted to investigate the prevalence of quinolone resistance associated qnr antibiotic resistance among escherichia coli strains isolated.

In the present study, we searched for the prevalence of plasmid mediated quinolone resistance pmqr genes within the 55 oxyiminocephalosporinresistant enterobacteria collected in a previous survey. Abstract the aim of this study was to investigate the prevalence of plasmid mediated quinolone resistance pmqr determinants in escherichia coli isolated from foodproducing animals and to charact. Quinolone resistance encoded by the qnr gene and mediated by plasmid pmg252 was discovered in a clinical strain of klebsiella pneumoniae that was isolated in 1994 at the university of alabama at birmingham medical center. The increase in plasmidmediated quinolone resistance among nts isolated from humans in the united states. Prevalence of plasmidmediated quinolone resistance determinants over a 9 year period. Epidemiology of plasmidmediated quinolone resistance in. Chromosomal mutations and plasmid mediated quinolone resistance pmqr determinants have been implicated. The gene codes for a protein that protects dna gyrase from quinolone inhibition and that belongs to the pentapeptide repeat family of proteins. Pdf resistance to quinolone has increased significantly and one of the most reasons is plasmidmediated quinolone resistance pmqr. Prevalence of extended spectrum beta lactamase and. High incidence of plasmidmediated quinolone resistance genes. Prevalence of plasmidmediated quinolone resistance and mutations in the gyrase and topoisomerase iv genes in salmonella isolated from 12 tertiarycare hospitals in korea. Resistance to fluoroquinolones fq in uropathogenic escherichia coli upec has emerged as a growing problem.

The traditional understanding that quinolone resistance is acquired only through mutation and transmitted only vertically does not entirely account for the relative ease with which resistance develops in exquisitely susceptible organisms, or for the very strong association between resistance to quinolones and to other. Prevalence of the plasmidmediated quinolone resistance determinants among clinical isolates of shigella sp. The purpose of this study was to investigate the prevalence and characteristics of plasmid mediated quinolone resistance pmqr genes qnr, aac6. Plasmid mediated quinolone resistance pmqr plays an important role in the development of clinical resistance to quinolone. Research article prevalence of plasmidmediated quinolone. Prevalence of plasmid mediated quinolone resistance genes. The bestdescribed form of pmqr is determined by the qnr group of genes. Prevalence and characterization of plasmidmediated quinolone resistance genes among escherichia coli strains isolated from different water sources in alborz province, iran background. The rates of quinolone resistance in clinical isolates of e. The purpose of this study was to investigate the prevalence and characteristics of plasmidmediated quinolone resistance pmqr genes qnr, aac6. The prevalence of plasmidmediated quinolone resistance and. Hongxia jiang, dian tang, yahong liu, xiaohua zhang, zhenling zeng, li xu, peter m. The prevalence of plasmidmediated quinolone resistance and esblproduction in enterobacteriaceae isolated from urinary tract infections robab azargun,1,2 mohammad reza sadeghi,3 mohammad hossein soroush barhaghi,2 hossein samadi kafil,2,4 fatemeh yeganeh,2 mahin ahangar oskouee,2 reza ghotaslou1,2 1infectious and tropical diseases research center, tabriz university of medical.

The prevalence of the gene has been investigated by using pcr with qnrspecific primers with a sample of more than 350 gramnegative strains that originated in 18 countries and 24 states in the united states and that included many strains with plasmid mediated ampc or extended spectrum betalactamase enzymes. Prevalence of plasmidmediated quinolone resistance and. Prevalence of extended spectrum beta lactamase and plasmid. Dec 08, 2008 recently, several plasmid mediated quinolone resistance pmqr genes conferring low levels of quinolone resistance have been discovered. Chromosomal mutations and plasmidmediated quinolone resistance pmqr determinants have been implicated. In the present study, we searched for the prevalence of plasmidmediated quinolone resistance pmqr genes within the 55 oxyiminocephalosporinresistant enterobacteria collected in a previous survey. The qnr gens presence were significantly correlated with amikacin p plasmid mediated quinolone resistance was thus rare in the sample examined. Ibcr, and qepa among ceftiofurresistant enterobacteriaceae isolates from companion and foodproducing animals. This study aims to evaluate the emergence of plasmid mediated quinolone resistance pmqr genes among enterobacterial isolates from morocco. Infection and drug resistance the prevalence of plasmidmediated quinolone resistance and esblproduction in enterobacteriaceae isolated from urinary tract infections mohammad reza sadeghi 0 mohammad hossein soroush barhaghi 1 hossein samadi kafil 1 3 fatemeh yeganeh 1 mahin ahangar oskouee 1 reza ghotaslou 1 2 0 azad university of macu, macu, iran 1 microbiology department.

The main aims of this study were to detect qnrencoding genes and to. Prevalence of plasmidmediated quinolone resistance in multidrugresistant gram negative bacilli in egypt. Prevalence and characterization of plasmidmediated quinolone. Recently, several plasmidmediated quinolone resistance pmqr genes conferring low levels of quinolone resistance have been discovered. Abstract the aim of this study was to investigate the prevalence of plasmidmediated quinolone resistance pmqr determinants in escherichia coli isolated from. Pdf prevalence and genetic analysis of plasmidmediated. The prevalence of three plasmidmediated quinolone resistance determinants, qnra, qnrb, and qnrs, among 526 nonreplicate clinical isolates of enterobacter cloacae collected at a taiwanese. The worldwide emergence of plasmidmediated quinolone resistance. To evaluate the temporal change in the prevalence of pmqr genes over a decade in a tertiary hospital in the republic. Prevalence of plasmidmediated quinolone resistance genes among ciprofloxacinnonsusceptible escherichia coli and klebsiella pneumoniae isolated from blood cultures in korea canadian journal of infectious diseases and medical microbiology, sep 2019. Prevalence of plasmidmediated quinolone resistance genes among ciprofloxacinnonsusceptible escherichia coli and klebsiella pneumoniae isolated from blood cultures in korea. Prevalence of plasmid mediated quinolone resistance and mutations in the gyrase and topoisomerase iv genes in salmonella isolated from 12 tertiarycare hospitals in korea. Ibcr and qepa genes was evaluated in a collection of 281 nalidixic acidresistant enterobacterial isolates recovered between september 2005 and december 2007 at the sahloul hospital, sousse, tunisia.

Prevalence and characterization of plasmidmediated. Prevalence of plasmid mediated quinolone resistance determinants among clinical isolates of escherichia coli in a tunisian hospital m. The prevalence of blactxm, blatem1 and blatem206 genes was 19. The main pmqr determinants were aac6ibcr and qnrb, which had. Prevalence of plasmidmediated quinolone resistance genes in escherichia coli and klebsiella pneumoniae isolates among the 102 isolates, 12. Prevalence of plasmidmediated quinolone resistance.

Among these isolates, the positive rate for the plasmidmediated quinolone resistance pmqr determinant was 14. Plasmid mediated quinolone resistance pmqr has received considerable attention recently. Pdf prevalence and characterization of plasmidmediated. Nabil karah may 2008 department of microbiology and virology institute of medical biology university of tromso reference centre for detection of antimicrobial resistance. Mechanisms prevalence of plasmidmediated quinolone resistance genes in clinical enterobacteria from argentina ezequiel albornoz,1 celeste lucero,1 genara romero,1 mara paula quiroga,2 melina rapoport,1 leonor guerriero,1 patricia andres,1 cecilia rodriguez,2 whonetargentina group, marcelo galas,3 daniela centro. Prevalence of plasmidmediated quinolone resistance determinants. The main pmqr determinants were aac6ibcr and qnrb, which had prevalence rates of 42. High prevalence of plasmidmediated quinolone resistance determinants qnr, aac6. The prevalence of plasmidmediated quinolone resistance pmqr determinants qnra, qnrb, qnrs, aac6. This first nationwide study was conducted to analyze the prevalence of plasmidmediated quinolone resistance.

Prevalence of plasmidmediated quinolone resistance determinants among clinical isolates of escherichia coli in a tunisian hospital m. This is the first report of the occurrence of extended spectrum betalactamase and plasmid mediated quinolone. Typhimurium dt104 from different dairy cows on a single farm in 2006 and 2007. Few reports regarding the prevalence of pmqr are available from india. The prevalence of carbapenemase genes and plasmidmediated. The spread of plasmidmediated quinolone resistance determinants qnrlike determinants, aac6. Prevalence of plasmid mediated quinolone resistance genes among extendedspectrum lactamaseproducing klebsiella pneumoniae human isolates in iran ehsanehshams, 1 farzanehfiroozeh, 1 rezvanmoniri, 1 andmohammadzibaei 2 department of microbiology and immunology, school of medicine, kashan university of medical sciences, p. High prevalence of plasmid mediated quinolone resistance determinants in commensal members of the enterobacteriaceae in ho chi minh city, vietnam. Pdf prevalence of plasmidmediated quinolone resistance. Summary although plasmid mediated quinolone resistance pmqr was thought not to exist before its discovery in 1998, the past decade has seen an explosion of research characterizing this phenomenon. High prevalence of plasmid mediated quinolone resistance genes qnr and aac6ibcr in clinical isolates of enterobacteriaceae from nine teaching hospitals in china.

The worldwide emergence of plasmidmediated quinolone. Inappropriate use of antibiotics in clinical settings is thought to have led to the global emergence and spread of multidrugresistant pathogens. The goal of this study was to investigate the prevalence of genes encoding aminoglycoside resistance and plasmidmediated quinolone resistance among clinical isolates of klebsiella pneumoniae. This study aims to evaluate the emergence of plasmid mediated quinolone resistance pmqr. Quinolones have a powerful antimicrobial activity and are frequently prescribed in general medicine. These genes, likely originating in aquatic organisms, code for pentapeptide repeat proteins. Pdf this first nationwide study was conducted to analyze the prevalence of plasmidmediated quinolone resistance pmqr genes in phenotypically. Plasmidmediated quinolone resistance pmqr plays an important role in the development of clinical resistance to quinolone. This first nationwide study was conducted to analyze the prevalence of plasmid mediated quinolone resistance. Ibcr, and qepa was investigated in a collection of 47 extendedspectrum. Short report open access epidemiology of plasmidmediated.

Fluoroquinolone resistance is emerging in gramnegative pathogens worldwide. Prevalence of plasmid mediated quinolone resistance genes among ciprofloxacinnonsusceptible escherichia coli and klebsiella pneumoniae isolated from blood cultures in korea. The quinoloneresistance determining regions qrdrs analysis for the pmqrpositive isolates showed that the. Plasmidmediated quinolone resistance pmqr is a growing clinical concern worldwide. The prevalence of qnr and qepa genes in 660 escherichia coli isolates was investigated in healthy animals from 30 pig farms and 30 chicken farms. Characterization of plasmidmediated quinolone resistance by the. Prevalence of plasmidmediated quinolone resistance in. The prevalence of carbapenem resistance in enterobacteriaceae was 10% 515012. The majority of isolates originated from highdependency care units. Celular and molecular research center, qazvin university of medical sciences, qazvin.

The prevalence of plasmidmediated quinolone resistance genes. High prevalence of plasmidmediated quinolone resistance genes qnr and aac6ibcr in clinical isolates of enterobacteriaceae from nine teaching hospitals in china. A total of 225 isolates of salmonella enterica serovar typhimurium from foodproducing animals collected between 2003 and 2007 were examined for the prevalence of plasmid mediated quinolone resistance pmqr determinants, namely qnra, qnrb, qnrc, qnrd, qnrs, qepa and aac6ibcr, in japan. Chang, joseph jeong, jihyun cho, mina kim, sunjoo kim, young ree kim, chae hoon lee, kyungwon lee, mi ae lee. Prevalence and characteristics of extendedspectrum. High prevalence of plasmid mediated quinolone resistance determinants in enterobacter cloacae isolated from hospitals of the qazvin, alborz, and tehran provinces, iran amir peymani1, taghi naserpour farivar1, reza najafipour1 and samaneh mansouri1 1. Plasmid pmg252, which mediates lowlevel quinolone resistance, was discovered in a klebsiella pneumoniae strain that was isolated in july 1994 from the urine of a patient at the university of alabama at birmingham medical center uab 9. Prevalence of plasmidmediated quinolone resistance genes. Prevalence of plasmidmediated quinolone resistance ncbi. High prevalence of plasmidmediated quinolone resistance determinants in commensal members of the enterobacteriaceae in ho chi minh city, vietnam. Among 6,057 isolates, 17 qnrpositive isolates and 1 aac6.

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